They present with signs of GH deficiency, delayed puberty, glucocorticoid deficiency and/or hypothyroidism. Rarely, precocious puberty occurs with craniopharyngioma. Calcification of the sella turcica or suprasellar area occurs in seventy to eighty per cent of cases with craniopharyngioma, and erosion of the sella turcica or clinoid processes is common. Smaller craniopharyngiomas can be resected by transsphenoidal microsurgery, but larger ones will require intracranial surgery. Radiotherapy is useful for incompletely removed tumours.